Immundot image found here.
It's a story that I've heard over and over from frustrated readers: "I have all of the symptoms on Sjogren's syndrome, but the doctor told me that my blood doesn't have the anti-SSA/SSB antibodies. I wish that I knew what was making me feel so sick."
For these patients, an invasive and uncomfortable lip biopsy could be next in the diagnostic process, which may or may NOT prove the presence of Sjogren's syndrome.
It appears that another test may be available in the future which would offer patients and their health care teams another clue to their illness' identity. Thanks to the Sjogrens Soc. Canada's tweet that alerted me to this recently published study, found here:
Anti-SSA Ro52/Ro60 antibodies testing by immunodot could help the diagnosis of Sjogren's syndrome in the absence of anti-SSA/SSB antibodies by ELISA.
Mekinian A, Nicaise-Roland P, Chollet-Martin S, Fain O, Crestani B.
Rheumatology (Oxford). 2013 Sep 11. [Epub ahead of print]
Objective. The objective of this study was to assess the diagnostic value of anti-Ro52/60 antibodies by immunodot in patients with suspected SS..........Conclusion. In patients with dry eye/mouth syndrome without anti-SSA/SSB antibodies by ELISA, the detection of anti-Ro52/Ro60 antibodies by dot could help in the diagnosis of SS.
It will be interesting to see if this type of diagnostic test will be made available on a large scale any time soon. Let's keep our eyes peeled.